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pentobarbital will decrease the extent or effect of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Monitor Intently (1)pentobarbital will reduce the level or result of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Loss of, or lowered response to tofacitin